Artificial Insemination 2 types,one of them being IUI
- IUI – Intra-uterine insemination
- It is a process of putting the washed sperms into the woman’s uterus, bypassing the cervix, around the time of ovulation
- IUI is commonly used for : -
- Unexplained infertility – When the cause of infertility is not known despite all normal tests .
- severe endometriosis
- ovulation problem
- cervical problems- hostile cervical mucus, torn cervix due to prior surgery
Male Factor Problems Like
- Borderline sperm count
- low motility
- low sperm morphology
- Premature ejaculation
- Retrograde ejaculation (when semen is released into the urinary bladder)
- HIV Positive male – (sperm washing reduces the risk of transmission to the partner and future generation)
How is IUI done
The medication to stimulate ovary to produce eggs can be given to a woman starting from D2 to D5 of her cycle. The aim is to get one or maximum 2 mature eggs for fertilization. This is a stimulated cycle where fertility drugs are given.
In an unstimulated cycle, drugs are not given to stimulate the ovary. IUI is done around the time of natural ovulation.
An ultrasound helps us to monitor the follicle development and helps us to know the mature size of the follicle and egg release. This allows insemination at the best time. • A women may ovulate naturally or HCG hormone infection can be given to induce ovulation.
IUI can be done 24-40 hrs after HCG injection or after 12-48 hrs of LH surge IUI should logically be performed around the time of ovulation. Since spermatozoa & eggs have a limited life. Therefore correct time of insemination is essential for success.
- A semen sample is either given at home or preferably at clinic by masturbation after 2-3 days of abstinence .
- The sample is then washed or processed in the laboratory.
- The sperm is separated from the other components of the semen and concentrated in a small volume.
- Various media and techniques are used for sperm washing and the selective is made depending upon the semen analysis report.
- Sperm processing takes about 30-45minutes.
- After preparation of semen, the speculum is inserted into the vagina to visualize the cervix.
- Through a sterile flexible catheter the washed specimen of highly motile sperm are placed gently inside the uterus.
- The egg – sperm fertilization then happens naturally inside the uterus.
REST AFTER IUI
- 10 Minutes of bed rest is sufficient after IUI.
- If donor’s frozen sample is used, it will be first Thawed & then processed.
COMPLICATIONS OF THE PROCEDURE
- Related to ovulation induction there is a small risk of developing ovarian hyperstimulation syndrome. it can occur when ovaries hyper respond to the fertility drugs . the size of the ovaries increases to several times its normal size and can leak fluid in abdomen, which can lead to weight gain , nausea, vomiting and bloating sensation.
- A woman needs medical help in such a case and IUI should not be carried out. The risk of multiple pregnancies also increases due to fertility drugs.
- During the procedure, there may be a slight discomfort while inserting a catheter.
- At a maximum of 6cycles of IUI can be tried. If donor semen is used, 12cycles.